There is limited scientific evidence to directly link creatine supplementation to acne.
Acne is a skin condition primarily caused by factors such as excess sebum production, clogged hair follicles, bacterial activity, and inflammation. There is some speculation that creatine supplementation may increase the production of dihydrotestosterone (DHT), a hormone linked to acne development. However, the evidence supporting this connection is not substantial, and more research is needed to establish a definitive link.